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Biosketch
Positions:
- Associate Professor
Department of Chemistry, Indian Institute of Technology Palakkad, India
Duration: June 2023 - present - Assistant Professor
Department of Chemistry, Indian Institute of Technology Palakkad, India
Duration: July 2019 - May 2023
- Assistant Professor
Discipline of Biosciences & Biomedical Engineering, Indian Institute of Technology Indore, India
Duration: May 2017 - June 2019
- Postdoctoral Associate
Department of Chemistry and Chemical Biology, Cornell University, New York, USA
Duration: Sept 2012 - April 2017
Educations:
- Case Western Reserve University, Cleveland, Ohio, USA
Ph.D. in Chemistry (2012)
- Indian Institute of Technology Delhi, New Delhi, India
M.Sc. in Chemistry (2007) - University of Calcutta, West Bengal, India
B.Sc. in Chemistry (Hons.) (2005)
- Associate Professor
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Research
Chemical Biology
Bio-orthogonal probe development to investigate different protein post-translational modifications (PTMs) and their functions
Development of Small Molecule Inhibitors
Design, synthesis and pharmaceutical evaluation of inhibitors for key metabolic and epigenetic enzymes
Metabolomics
Identifying biomarkers for early detection of disease states. Uncovering the role of metabolism in the regulation of epigenetics
Proteomics
Protein-protein interaction, identification of key targets of various PTMs, phenotypic screening
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Teaching
At Indian Institute of Technology Palakkad (IIT Palakkad)
- CY 5017: Chemistry of Life (M.Sc. Course; Aug 2020)
- CY 5013: Synthetic Approaches in Chemistry (M.Sc. Course; Aug 2020)
- BT 2010: Life Sciences (B.Tech. Course; Aug 2020)
- CY 1140: Chemistry Lab (B.Tech. Course; Jan 2020)
- CY 5104: Synthesis, Energetics and Dynamics III (M.Sc. Course; Jan 2020)
- CY 1010: Thermodynamics, Kinetics, and Organic Reactions (B.Tech. Course; July 2019)
- BT 2010: Life Sciences (B.Tech. Course; July 2019)
At Indian Institute of Technology Indore (IIT Indore)
- BSE 608: Advanced Drug Delivery Systems (Ph.D. Course; Autumn 2017, 2018)
- BSE 651: Biochemistry Lab (M.Sc. Course; Autumn 2017)
- BSE 102: Biosciences (B.Tech. Course; Spring 2018, 2019)
- BSE 615: Principles of Chemical Biology (Ph.D. Course; Autumn 2018)
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Research Group
Ph.D. Students
Ms. Jissy Anna George, HTRA-JRF
M.Sc. (2021-2023) in Biochemistry from University of Hyderabad, Hyderabad
B.Sc. (2018-2021) in Biochemistry from Kerala University, Kerala
Joined: Jan 2024
Email: 172404001@smail.iitpkd.ac.in
Ms. Karthika K, PMRF
M.Sc. (2018-2020) in Chemistry from Govt. Victoria College Palakkad, Kerala
B.Sc. (2015-2018) in Chemistry from Govt. College Chittur, Kerala
Joined: Aug 2022
Email: 202214002@smail.iitpkd.ac.in
Mr. Vishnu NV, HTRA-JRF
M.Sc. (2019-2021) in Chemistry from the University of Calicut, Kerala
B.Sc. (2016-2019) in Chemistry from Sri Vyasa NSS College, Vyasagiri, Kerala
Joined: Aug 2022
Email: 202214009@smail.iitpkd.ac.in
Mr. Shabin NC, CSIR-SRF
M.Sc. (2018-2020) in Chemistry from the University of Calicut, Kerala
B.Sc. (2015-2018) in Chemistry from Govt. Arts & Science College Meenchantha, Kerala
Joined: Aug 2021
Email: 202114002@smail.iitpkd.ac.in
Ms. Revathy S, CSIR-SRF
M.Sc. (2015-2017) in Chemistry from Govt. Victoria College Palakkad, Kerala
B.Sc. (2012-2015) in Chemistry from Govt. Victoria College Palakkad, Kerala
Joined: Jan 2020
Email: 202004003@smail.iitpkd.ac.in
Mr. Satyam Singh, Institute Fellow-SRF (Continuing at IIT Indore, Thesis submitted)
M.Sc. (2016-2018) in Biotechnology from Madurai Kamaraj University, Madurai
B.Sc. (2013-2016) in Botany (Hons.) from Banaras Hindu University, Varanasi
Joined: July 2018
Email: phd1801171001@iiti.ac.in
Ms. Suchi Chaturvedi, DST-Inspire Fellow-SRF (Continuing at IIT Indore)
M.Sc. (2015-2017) in Biochemistry from Devi Ahilya Vishwavidyalaya, Madhya Pradesh
B.Sc. (2012-2015) in Biochemistry from Rani Durgavati Vishwavidyalaya, Madhya Pradesh
Joined: July 2018
Email: phd1801171002@iiti.ac.in
Alumni
Dr. Debashis Majee, Visiting scientist, April 2019-March 2020
Ms. Sai Kumari Vechalapu, M.Sc. project student, May 2018-June 2019
Mr. Indranil De, JRF, October 2017-October 2018
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Additional Information
TitleSelected Journal PublicationsDescription
Liya Thurakkal#, Satyam Singh#, Rajarshi Roy, Parimal Kar, Sushabhan Sadhukhan*, Mintu Porel*. An in-silico study on selected organosulfur compounds as potential drugs for SARS-CoV-2 infection via binding multiple drug targets. Chem. Phys. Lett. 2020, Just accepted. (#Equal contribution) DOI: 10.1016/j.cplett.2020.138193.
Satyam Singh, Md Fulbabu Sk, Avinash Sonawane, Parimal Kar, Sushabhan Sadhukhan*. Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA‐dependent RNA polymerase (RdRp) inhibition: An in-silico analysis. J. Biomol. Struct. Dyn. 2020, Just accepted. DOI: 10.1080/07391102.2020.1796810.
Indranil De, Sushabhan Sadhukhan*. Emerging Roles of DHHC-mediated Protein S-palmitoylation in Physiological and Pathophysiological Context. Euro. J. Cell Biol. 2018, 97, 319-338. Featured on the journal cover page.
Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella Nelson, John Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert Weiss, Jason Locasale, Johan Auwerx, and Hening Lin. Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Cardiac Function. Proc. Natl. Acad. Sci. U S A. 2016, 113, 4320-4325. (Highlighted on many science news outlets including Science Daily, EurekAlert!, Medical News Today, Scicasts)
Sushabhan Sadhukhan, Guo-Fang Zhang, and Gregory P. Tochtrop. Modular Isotopomer Synthesis of γ-Hydroxybutyric Acid for a Quantitative Analysis of Metabolic Fates. ACS Chem. Biol. 2014, 9, 1706-1711.
Sushabhan Sadhukhan, Yong Han, Zhicheng Jin, Gregory P. Tochtrop, and Guo-Fang Zhang. Glutathionylated 4-Hydroxyalkenal Enantiomers in Rat Organs and Its Contributions Towards the Disposal of 4-Hydroxynonenal in Rat Liver. Free Rad. Biol. Med. 2014, 70, 78-85.
Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Using Selective Isotopic Labeling to Quantitate Parallel Metabolic Pathways. J. Am. Chem. Soc. 2010, 132, 6309-631.
TitleResearch FundingTitleResearch & Academic Programs OrganizedDescription- Conducted a short-term course on “Advanced Biological and Chemical Understanding of Disease Diagnostics and Therapeutics” under Continuing Education Program (CEP) (May 17-19, 2018)
- Organized a two days international symposium entitled as “Emerging Areas in Biosciences and Biomedical Technologies (eBBT) 2018” at IIT Indore during January 5-6, 2018.
- Organized a one-day international symposium entitled as “Water: Resources, Challenges & Sustainability (WRCS)” at IIT Indore on March 10, 2018.
TitleHonors & AwardsDescription- ‘Early Career Research Award’ from the Science and Engineering Research Board (SERB), 2018
- Postdoc Leadership Certificate, Cornell University, Ithaca, NY, USA, 2016.
- Outstanding oral presentation at the Meeting in Miniature from American Chemical Society, Cleveland section, Cleveland, OH, USA, 2011.
- Conference Travel Award from Gordon Research Conference based on excellent poster presentation, Boston, MA, USA, 2011.
- Second prize in Research Showcase, Case Western Reserve University, Cleveland, OH, USA, 2010.
- Conference Travel Award from the Division of Biological Chemistry of American Chemical Society, San Francisco, CA, USA, 2010.
- Endowment Sponsored Mentorship Award, Case Western Reserve University, Cleveland, OH, USA, 2010.
- Merit-Cum-Means (MCM) Scholarship, Indian Institute of Technology Delhi, India, 2005-07.
- S. J. Jindal Trust Scholarship, New Delhi, India, 2004.
TitleProfessional ServicesDescriptionMember of Board of Research (BoR) of IIT Palakkad (2019-2020)
Institute colloquium organizer at IIT Palakkad (2019-2020)
Biology coordinator for DST-sponsored Vigyan Jyoti Program (May 2018) at IIT Indore
Member Secretary of IIT Indore-Institutional Committee for Stem Cell Research (2017-2019)
Reviewer for the following peer-reviewed journals: (i) Scientific Reports, (ii) Proteomics, (iii) ACS Applied Materials & Interfaces, (iv) PLoS One, (v) Cell Communication and Signaling.
Served as a reviewer for the undergraduate summer funding applications from Support of Undergraduate Research & Creative Endeavors (SOURCE), Case Western Reserve University, Cleveland, OH, USA, 2011.
Served as a judge for the undergraduate poster presentation in SOURCE Symposium & Poster Session, Case Western Reserve University, Cleveland, OH, USA, 2010.
Member of American Chemical Society (ACS), 2010-current
Member of Society of Biological Chemists, India (SBCI), Life member
TitleSelected Oral PresentationsDescriptionUnderstanding the Mechanism of Action of (–)-Epigallocatechin-3-gallate (EGCG), A Major Green Tea Polyphenol. Advances at the Interface of Biology & Chemistry, BARC, Mumbai, India, Nov 1-3, 2019.
Protein Post-Translational Modifications (PTMs): Small Changes, Big Impact. Mitochondria & Metabolism Network Meeting, IISER Pune, India, November 10-11, 2017.
Metabolomics-assisted Proteomics Identifies Protein Lysine Succinylation and SIRT5 as Important Regulators of Cardiac Metabolism and Function. 252nd American Chemical Society National Meeting, Philadelphia, PA, USA, August 21, 2016.
Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Cardiac Function. Cornell University, Ithaca, NY, USA, November 13, 2015.
Protein modifications: When, how, where and so what? Young Investigator Meeting, Massachusetts Institute of Technology, Boston, MA, USA, October 11, 2015.
A Modular Isotopomer Synthesis of gamma-Hydroxybutyrate (GHB) Reveals Catabolism via Alpha Oxidation. ACS Meeting in Miniature, Ursuline College, Cleveland, OH, USA, March 16, 2011.
A Modular Isotopomer Synthesis of gamma-Hydroxybutyrate (GHB) Reveals Catabolism via Alpha Oxidation. Departmental Retreat, Case Western Reserve University, Cleveland, OH, USA, October 30, 2010.
Metabolism of 4-Hydroxy Acids: Using a Selective Isotope Labeling Strategy. Departmental Retreat, Case Western Reserve University, Cleveland, OH, USA, October 3, 2009.
TitleSelected Conference (poster) PresentationsDescriptionSai K Vechalapu, and Sushabhan Sadhukhan*. Understanding the Mechanism of Action of (–)-Epigallocatechin-3-gallate (EGCG), A Major Green Tea Polyphenol. 1st In-house Symposium on Advances in Biosciences and Bioengineering, Indian Institute of Technology Indore, India, February 23, 2019.
Satyam Singh, Suchi Chaturvedi, and Sushabhan Sadhukhan*. Chemical Biology of DHHC-mediated Protein S-palmitoylation and Dissecting Its Roles in Breast Cancer. Industry-Academia Conclave 2018 (IAC-2018), Indian Institute of Technology Indore, India, November 20, 2018.
Sushabhan Sadhukhan, Xiaojing Liu, Ornella Nelson, John Stupinski, Sheng Zhang, Robert Weiss, Jason Locasale, and Hening Lin. Metabolomics-assisted Proteomics Reveals the Function of Lysine Succinylation and SIRT5 in Regulation of β-Oxidation of Long-chain Fatty Acids. 64th American Society for Mass Spectrometry Conference, San Antonio, Texas, USA, June 5-9, 2016.
Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella D. Nelson, Hening Lin. Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Heart Function. Chemistry Biology Interface Symposium, Cornell University, Ithaca, New York, USA, March 7, 2015.
Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolomics of Lipid Peroxidation Products Using a Selective Isotope Labeling Strategy. Gordon Research Conferences (Molecular and Cellular Biology of Lipids), Waterville Valley, New Hampshire, USA, July 17-22, 2011.
Sushabhan Sadhukhan, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of Lipid Peroxidation Products Using a Selective Isotope Labeling Strategy. 42nd National Organic Symposium, Princeton University, New Jersey, USA, June 5-9, 2011.
Sushabhan Sadhukhan, Guo-Fang Zhang, Tonibelle Gatbonton-Schwager, Henri Brunengraber, and Gregory P Tochtrop. The Metabolism and Signaling of the Lipid Peroxidation Product 4-HNE. American Association for Cancer Research and American Chemical Society Joint Meeting, San Diego, California, USA, January 30-February 2, 2011.
Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism and Signaling of Lipid Peroxidation Products. Gordon Research Conferences (Bioorganic Chemistry), Andover, New Hampshire, USA, June 13-18, 2010.
Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of 4-Hydroxyacids and 4-Hydroxynonenal Using a Selective Isotope Labeling Strategy. Research Showcase, Case Western Reserve University, Cleveland, Ohio, USA, April 15, 2010.
Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of 4-Hydroxyacids and 4-Hydroxynonenal Using a Selective Isotope Labeling Strategy. 239th American Chemical Society National Meeting, San Francisco, California, USA, March 21-25, 2010
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Publications
Sahadevan, R.; Kannan, K.; Jose, A.; Porel, M.*; Sadhukhan, S.*Sens. Actuators B Chem in press 135589 (2024)Kothari, M.; Kannan, K.; Sahadevan, R.; Sadhukhan, S.*Int. J. Biol. Macromol. 263 130175 (2024)Chaturvedi, S.; Pandya, N.; Sadhukhan, S.; Sonawane, A.*J Biomol. Struct. Dyn. in press (2024)Binoy, A.; Kothari, M. ; Sahadevan, R. ; Poddar, S.; Kar, P.; Sadhukhan, S.*Biochim. Biophys. Acta Biomembr. 1866 184264 (2024)Jose, A.; Vijayan, V. N.; Sahadevan, R.; Porel, M.*; Sadhukhan, S.*Microchem. J. 197 109802 (2024)Vignesh, A.; Binoy, A.; Thurakkal, L.; Bhuvanesh, N.S.P.; Sadhukhan, S.*; Porel, M.*J. Mol. Struct. 1295 136693 (2024)Singh, S.; Ghosh, P.; Roy, R.; Behera, A.; Sahadevan, R.; Kar, P.; Sadhukhan, S.*; Sonawane, A.*ACS Omega 9 2286 (2024)Sahadevan, R. ; Binoy, A. ; Shajan, I.; Sadhukhan, S.*RSC Adv. 13 29477 (2023)Singh, S.; Sadhukhan, S.*; Sonawane, A.*Biochim. Biophys. Acta: Rev. Cancer 1878 188967 (2023)Sahadevan, R.; Jose, A.; Porel, M.*; Sadhukhan, S.*J. Photochem. Photobiol. A Chem. 445 115086 (2023)Chaturvedi, S.; Biswas, M.; Sadhukhan, S.*; Sonawane, A.*J. Cell. Commun. Signal. 17 1249 (2023)Jose, A.; Chathangad, S. N.; Sahadevan, R.; Binoy, A.; Vignesh, A.; Sadhukhan, S.*; Porel, M.*J. Photochem. Photobiol. A Chem. 444 114950 (2023)Sahadevan, R., Binoy, A., Vechalapu, S.K., Nanjan, P., Sadhukhan, S.*Int. J. Biol. Macromol. 237 123991 (2023)Jose, A., Sahadevan, R., Vijay, M, Sadhukhan, S.*, Porel, M.*Sens. Actuators B Chem 380 133335 (2023)Revathy Sahadevan, Satyam Singh, Anupama Binoy, Sushabhan Sadhukhan*Crit. Rev. Food. Nutr. Sci. 63 10382 (2023)Satyam Singh, Revathy Sahadevan, Rajarshi Roy, Mainak Biswas, Priya Ghosh, Parimal Kar, Avinash Sonawane, Sushabhan Sadhukhan*RSC Adv. 12 17821 (2022)Yashira L. Negrón Abril, Irma R. Fernandez, Jun Young Hong, Ying-Ling Chiang, Dennis A. Kutateladze, Qingjie Zhao, Min Yang, Jing Hu, Sushabhan Sadhukhan, Bo Li, Bin He, Brenna Remick, Jessica Jingyi Bai, James Mullmann,.... Hening Lin, Robert S. Weiss.Oncogene 40 1644–1658 (2021)Liya Thurakkal, Satyam Singh, Rajarshi Roy, Parimal Kar, Sushabhan Sadhukhan*, Mintu Porel*Chem. Phys. Lett. 763 138193 (2021)Satyam Singh, Md Fulbabu Sk, Avinash Sonawane, Parimal Kar, Sushabhan Sadhukhan*J. Biomol. Struct. Dyn. 39 (16) 6249-6264 (2021)Nicole A. Spiegelman, Ian R. Price, Hui Jing, Miao Wang, Min Yang, Ji Cao, Jun Young Hong, Xiaoyu Zhang, Pornpun Aramsangtienchai, Sushabhan Sadhukhan, and Hening Lin.ChemMedChem. 13 1890-1894 (2018)Indranil De, Sushabhan Sadhukhan*Euro. J. Cell Biol. 97 319-338 (2018)Zhen Tong, Miao Wang, Yi Wang, David D. Kim, Jennifer K. Grenier, Ji Cao, Sushabhan Sadhukhan, Quan Hao, and Hening Lin.ACS Chem. Biol. 12 300-310 (2017)Zhen Tong, Yi Wang, Xiaoyu Zhang, David D. Kim, Sushabhan Sadhukhan, Quan Hao, and Hening Lin.ACS Chem. Biol. 11 742-747 (2016)Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella Nelson, John Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert Weiss, Jason Locasale, Johan Auwerx, and Hening Lin.Proc. Natl. Acad. Sci. USA. 113 4320-4325 (2016)Xiaojing Liu, Sushabhan Sadhukhan, Shengyi Sun, Gregory R. Wagner, Matthew D. Hirschey, Ling Qi, Hening Lin, and Jason W. Locasale.Mol. Cell. Proteomics 14 1489-1500 (2015)Tonibelle N. Gatbonton-Schwager, Sushabhan Sadhukhan, Guo-Fang Zhang, John J. Letterio, and Gregory P. Tochtrop.Redox Biol. 2 755-763 (2014)Sushabhan Sadhukhan, Yong Han, Zhicheng Jin, Gregory P. Tochtrop, and Guo-Fang Zhang.Free Rad. Biol. Med. 70 78-85 (2014)Sushabhan Sadhukhan, Guo-Fang Zhang, and Gregory P. Tochtrop.ACS Chem. Biol. 9 1706-1711 (2014)Zhicheng Jin, Jessica M. Berthiaume, Qingling Li, Fabrice Henry, Zhong Huang, Sushabhan Sadhukhan, Peng Gao, Gregory P. Tochtrop, Michelle A. Puchowicz and Guo-Fang Zhang.J. Biol. Chem. 289 32327-32338 (2014)Qingling Li, Sushabhan Sadhukhan, Jessica M. Berthiaume, Rafael A. Ibarra, Hui Tang, Shuang Deng, Eric Hamilton, Laura E. Nagy, Gregory P. Tochtrop, and Guo-Fang Zhang.Free Rad. Biol. Med. 58 35-44 (2013)Stephanie R. Harris, Guo-Fang Zhang, Sushabhan Sadhukhan, Hua Wang, Chuan Shi, Michelle A. Puchowicz, Vernon E. Anderson, Robert G. Salomon, Gregory P. Tochtrop, and Henri Brunengraber.Chem. Res. Toxicol. 26 213-220 (2013)Jiujiu Yu, Sushabhan Sadhukhan, Lilia G. Noriega, Norman Moullan, Bin He, Robert S. Weiss, Hening Lin, Kristina Schoonjans, and Johan Auwerx.Sci. Rep. 3 2806 (2013)Guo-Fang Zhang, Sushabhan Sadhukhan, Gregory P Tochtrop, and Henri Brunengraber.Biochem. J. 444 333-341 (2012)Guo-Fang Zhang, Sushabhan Sadhukhan, Gregory P. Tochtrop, and Henri Brunengraber.J. Biol. Chem. 286 23631-23635 (2011)Kristyen Tomcik, Rafael A. Ibarra, Sushabhan Sadhukhan, Yong Han, Gregory P. Tochtrop, and Guo-Fang Zhang.Anal. Biochem. 410 110-117 (2011)Stephanie R. Harris, Guo-Fang Zhang, Sushabhan Sadhukhan, Anne M. Murphy, Kristyen A. Tomcik, Edwin J. Vazquez, Vernon E. Anderson, Gregory P. Tochtrop, and Henri Brunengraber.J. Biol. Chem. 286 5895-5904 (2011)Enakshi Chakrabarti, Subrata Ghosh, Sushabhan Sadhukhan, Lawrence Sayre, Gregory P. Tochtrop, and Jonathan D. Smith.J. Med. Chem. 53 5302-5319 (2010)Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop.J. Am. Chem. Soc. 132 6309-6311 (2010)Guo-Fang Zhang, Rajan S. Kombu, Takhar Kasumov, Yong Han, Sushabhan Sadhukhan, Jianye Zhang, Lawrence M. Sayre, Dale Ray, K. Michael Gibson, Vernon A. Anderson, Gregory P. Tochtrop and Henri Brunengraber.J. Biol. Chem. 284 33521-33534 (2009)Gregory P. Tochtrop, Sushabhan Sadhukhan, Rik Rani Koner, and Subrata Ghosh.Tetrahedron 65 10515-10534 (2009)Abir B. Majumder, Bhupender Singh, Debjit Dutta, Sushabhan Sadhukhan, and Munishwar N. Gupta.Bioorg. Med. Chem. Lett. 16 4041-4044 (2006)